ABSTRACT
Objective To explore the impact factors of liver uptake of 18F-FDG in PET/CT imaging,and to preliminary analyze the application of maximum standardized uptake values corrected by conventional body mass,lean body mass and body surface area (SUVmax-B,SUVmax-L,SUVmax-S).Methods A retrospective analysis was performed on 67 healthy subjects who underwent 18F-FDG PET/CT.SUVmax-B,SUVmax-L and SUVmax-S were measured,and the impact of age,levels of fasting blood glucose,body mass index (BMI),CT value of liver,gender and the fatty liver on SUVmax-B,SUVmax-L and SUVmax-S were analyzed.Results The liver SUVmax-B,SUVmax-L,SUVmax-S were positively correlated with the levels of fasting blood glucose (r=0.329,0.336,0.353,P =0.012,0.010,0.007).There was a positive correlation between BMI and SUVmax-B (r=0.543,P＜0.01),SUV-L (r=0.328,P=0.007),while BMI value had no correlation with SUVmax-S (r=0.026,P=0.833).There was no correlation between age,CT value of the liver nor SUVmax-B,SUVmax-L and SUVmax-S (all P＞0.05).The liver SUVmax-B (t=2.608,P=0.011) and SUVmax-L (t=5.272,P=0.001) of male were significantly higher than those of female,while there was no difference between male's and female's liver SUVmax-S and liver SUVmax-S (t=0.759,P=0.450).There was no difference in SUVmax-B,SUVmax-L nor SUVmax-S between fatty liver subjects and non-fatty liver subjects (P=0.646,0.775,0.068).Conclusion The fasting blood glucose level,BMI and sex are the impact factors of liver uptake of 18F-FDG in PET/CT imaging.SUVmax-B can be replaced by SUVmax-L or SUVmax-S for larger BMI subjects,while SUVmax-S can make up differences between different genders.However,correction techniques can not weaken the impact of blood glucose level on SUVmax value of liver.